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According to a recently proposed hierarchical oxidative stress model, [8, 9] a low level of oxidative stress, such as exposure to diesel exhaust products for 6 hours at a concentration of 10 to 50 g/mL, [10] leads to the activation of the transcription factor, nuclear erythroid 2 p45-related factor 2 (Nrf2), which encodes more than 200 genes

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That said, a significant die-off reaction can also be a signal that detoxification pathways need more supportmore on this below

Although the body doesn't absorb this version as quickly as it does the others, its antioxidant content is known to lighten skin

doi: 10.1136/annrheumdis-2020-218469 122 KongRWangNHanWBaoWLuJ